MBP, MAPK Substrate - (5-TAMRA) labeled

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Synonyms: 5-TMR-APRTPGGRR

Functional Activity:

This peptide is fluorescently labeled with 5-TAMRA (Abs/Em=544/572 nm) on the N-terminus. The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. This substrate is specific for MAP kinases: p44 MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42 MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. This peptide is the most efficient substrate for phosphorylation reaction by ERK. The substrate is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38.

Technical Data:

M.Wt: 1379.6

Sequence (one-letter code): 5-TMR-APRTPGGRR

Sequence (three-letter code): 5 - TMR - Ala - Pro - Arg - Thr - Pro - Gly - Gly - Arg - Arg - OH

Excitation (nm): 547

Emission (nm): 573

Solubility: Soluble in DMSO

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

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References for MBP, MAPK Substrate - (5-TAMRA) labeled :

1. Sommer, F. et al. Int. J. Impot. Res. 14, 217 (2002);

2. Lents, NH. et al. Ann. N. Y. Acad. Sci. 973, 265 (2002);

3. Kameshita, I. et al. J. Biochem. (Tokyo) 122, 168 (1997).

Certificate of Analysis/MSDS is available upon request

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