EGF Receptor Substrate 2 - (5-FAM) labeled

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Synonyms: 5-FAM-DADE-pY-LIPQQG

Functional Activity:

The unlabeled phosphopeptide is an excellent substrate for mammalian protein tyrosine phosphatase 1B (Km = 3.9 &my;M) and Yersinia PTP. The sequence is derived from an autophosphorylation site (Tyr992) of EGFR. The unlabeled peptide is used to assay PTB based on marked fluorescence increase upon the removal of the phosphate group (Em = 305 nm and Ex = 282 nm).

Technical Data:

M.Wt: 1686.6

Sequence (one-letter code): 5-FAM-DADE-pY-LIPQQG

Sequence (three-letter code): 5 - FAM - Asp - Ala - Asp - Glu - pTyr - Leu - Ile - Pro - Gln - Gln - Gly - OH

Excitation (nm): 282

Emission (nm): 305

Solubility: Soluble in DMSO

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

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References for EGF Receptor Substrate 2 - (5-FAM) labeled :

1. Ukkola, O. and MJ. Santaniemi, Intern. Med. 251, 467 (2002)

2. Sarmiento, M. et al. J. Biol. Chem. 273, 26368 (1998);

3. Zhang, ZY. et al. Anal. Biochem. 211, 7 (1993).

Certificate of Analysis/MSDS is available upon request

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