5 - FAM - KRREILSRRPSYR (PKA substrate)

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Synonyms: CREBtide [KRREILSRRPSYR], 5 - FAM labeled

Functional Activity:

CREBtide is a synthetic substrate for PKA (Km = 3.9 μM). This peptide is based on the phosphorylation sequence in δ-CREB (cAMP response element binding protein).

Technical Data:

M.Wt: 2075.3

Sequence (one-letter code): 5-FAM-KRREILSRRPSYR

Sequence (three-letter code): 5 - FAM - Lys - Arg - Arg - Glu - Ile - Leu - Ser - Arg - Arg - Pro - Ser - Tyr - Arg - OH

Excitation (nm): 494

Emission (nm): 521

Solubility: Soluble in DMSO

Purity: >95% (HPLC)

Shipping Conditions: Room temperature

Storage: Store and desiccate at -20°C and protect from light.

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References for 5 - FAM - KRREILSRRPSYR :

1. Bok, J. et al. J. Neurosci. 23, 777 (2003).

2. Yamagata, Y. et al. J. Biol. Chem. 266, 15391 (1991).

3. Colbran, JL. et al. Biochem. Cell Biol. 70, 1277 (1992).

Certificate of Analysis/MSDS is available upon request

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