Neurogranin (28 - 43) - (5-FAM) labeled
Catalog #:
ABBFO2045Shipping advice for credit card purchase:
Suitable for Two-Day Shipping (2-3 Days). For international shipping rate please contact us for details
ABBFO2045-1mg | USD229.0 |
Synonyms: 5-FAM-AAKIQASFRGHMARKK
Functional Activity:
The native peptide AAKIQASFRGHMARKK is a synthetic PKC substrate generated from the sequence of neurogranin, a naturally occurring PKC substrate. No significant phosphorylation of the peptide by either PKA or by CaMK 2 is reported. Substituting Arg36 with Ile results in a significant reduction in the affinity for PKC. Replacing Lys30 with Arg uplifts the catalytic efficiency for PKC but diminishes the selectivity of the substrate of PKC. It is generally considered that basic amino acids on both sides of the phosphorylated Ser are important structural determinants in PKC substrates. In addition, the presence of particular basic amino acids may also contribute to the degree of selectivity of a substrate of PKC.
Technical Data:
M.Wt: 2158.2
Sequence (one-letter code): 5-FAM-AAKIQASFRGHMARKK
Sequence (three-letter code): 5 - FAM - Ala - Ala - Lys - Ile - Gln - Ala - Ser - Phe - Arg - Gly - His - Met - Ala - Arg - Lys - Lys - OH
Excitation (nm): 494
Emission (nm): 521
Solubility: Soluble in DMSO
Purity: >95% (HPLC)
Shipping Conditions: Room temperature
Storage: Store and desiccate at -20°C and protect from light.
Related Products by Target:
References for Neurogranin (28 - 43) - (5-FAM) labeled :
Certificate of Analysis/MSDS is available upon request
For bulk or custom order please contact us for details