Metabolite Identification and Profiling

AddexBio is able to identify, generate, and compare metabolite profiles to assist with species selection for toxicology studies. We will use the state-of-the-art mass spectrometry to analyze samples from in vitro metabolic stability assays or in vivo dosing studies. We search the data sets for potential metabolites, and compare the time profiles of parent compound loss and metabolite formation using enzyme sources from various animal species. Metabolite identification and profiling studies can also be specifically designed to look for unique or disproportionate human metabolites. We determine possible major metabolites using HPLC-UV detection and identify major metabolites using LC-MSⁿ and NMR methods.