Drug Metabolism and Clearance

AddexBio is expertise in performing studies on drug metabolic stability and clearance. While metabolic stability is helpful when trying to determine the potential half-life of a compound, the intrinsic clearance of drug candidates can help to confirm whether metabolism is the main clearance pathway when it is compared with the total body clearance in vivo. Our in vitro ADME metabolic stability and intrinsic clearance assays are conducted in liver microsomes, liver S9, cryopreserved hepatocytes from human, Cynomolgus monkey, Beagle dog, Sprague-Dawley rat, and CD-1 mouse. We also determine metabolic stability when a compound is dosed to animals DRUG METABOLISM & PHARMACOKINETICS. The time points are customized for each project, and the deliverables include raw data, percent remaining, and half-life values.