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Calcium Channel (Calcium Channel Assay)

Homology model of the TRPV1 ion channel

Calcium channel have been well recognized as therapeutic targets for treating a number of diseases. However, the calcium channel class is considered to be underexploited due to the lack of reliable functional cell-based assays for HTS. Utilizing novel fluorescent dyes, such as fluo-4 AM dye, we have completed implementation of HTS for several calcium channels, including TRPC and TRPV channels. With expertise on these channels, we offer calcium channel assay development for HTS services as well as screening and profiling services using Flexstation 3 and calcium imager. Utilizing digital cell Ca2+ imaging with fura-2 AM dye in single human living cells, we also offer [Ca2+]i measurement to test effects of lead compounds on GPCR-mediated [Ca2+]i signaling pathway, such as Ca-sensing receptor and other GPCR.

Price: US$50 for 1 concentration to 1 single cell with 1 Ca2+ channel or 1 receptor.

Related References to Calcium Channel Assay:

  1. Alcocer L, Bendersky M, Acosta J, and Urina-Triana M. Use of calcium channel blockers in cardiovascular risk reduction: issues in Latin America. Am J Cardiovasc Drugs 10: 143-154, 2010.
  2. Araie M and Mayama C. Use of calcium channel blockers for glaucoma. Prog Retin Eye Res 30: 54-71, 2010.
  3. Belardetti F. Evolving therapeutic indications for N-type calcium channel blockers: from chronic pain to alcohol abuse. Future Med Chem 2: 791-802, 2010.
  4. Costanzo P, Perrone-Filardi P, Petretta M, Marciano C, Vassallo E, Gargiulo P, Paolillo S, Petretta A, and Chiariello M. Calcium channel blockers and cardiovascular outcomes: a meta-analysis of 175,634 patients. J Hypertens 27: 1136-1151, 2009.
  5. Fujita M, Sasayama S, Terasaki F, Mitani S, Morimoto T, Yamazaki T, Hayashi D, Kohro T, Okada Y, and Nagai R. Treatment effects of renin-angiotensin system inhibitor and calcium channel blocker in patients with coronary artery narrowing (from the Japanese Coronary Artery Disease Study). Heart Vessels 25: 453-459, 2010.
  6. Kosaka T, Nakagawa M, Ishida M, Iino K, Watanabe H, Hasegawa H, and Ito H. Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease. J Cardiol 54: 262-272, 2009.
  7. N'Gouemo P, Faingold CL, and Morad M. Calcium channel dysfunction in inferior colliculus neurons of the genetically epilepsy-prone rat. Neuropharmacology 56: 665-675, 2009.
  8. Sumoza-Toledo A and Penner R. TRPM2: a multifunctional ion channel for calcium signalling. J Physiol 589: 1515-1525, 2010.
  9. Zhou Y, Meraner P, Kwon HT, Machnes D, Oh-hora M, Zimmer J, Huang Y, Stura A, Rao A, and Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol 17: 112-116, 2010.

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