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Heterobifunctional Linkers

Bioconjugation usually involves the joining (by chemical or biological methods) of molecules such as antibodies (their fragments), nucleic acids and their analogues, liposomal components, polysaccharides, hormones, proteins and peptides to drugs, radionuclides, toxins, fluorophores or photoprobes, inhibitors, enzymes and haptens. It may also involve the simple joining of two or more different biomolecules to combine their useful properties. Examples in this category include peptide-oligonucleotide, peptide-carbohydrate or oligonucleotide-carbohydrate conjugates and so on. To achieve this, the use of heterobifunctional linkers is essential. The requirements for bioconjugation are stringent, for instance the use of a largely aqueous medium, physiological pH, ambient temperature, short reaction time, equimolar proportions of the components and formation of stable linkages.

Addexbio is dedicated to designing and developing novel linkers for bioconjugation. Addexbio help the clients design linkers based on a variety of chemoselective ligation techniques and strategies.

Heterobifunctional Linkers available from AddexBio:

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1. G.T. Hermanson, BioconjugateTechniques, AcademicPress, NewYork, USA, 1996.

2. Bioconjugation Protocols: Strategies and Methods, ed. C. M. Niemeyer, Humana Press, New Jersey, USA, 2004.

3.Perspectives in Bioconjugate Chemistry, ed. C. F. Mears, American Chemical Society, Washington DC, 1993.

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